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Uyini umthombo we-rosmarinic acid?

Usuku: 2019-11-14


I-Rosmarinic acid (i-RosA, ifomula yama-molecule C18H16O8) inomsebenzi othile womzimba, futhi okuqukethwe okuphakeme kakhulu kutholakala ezitshalweni ezahlukahlukene, ikakhulukazi eLabiataceae nase-Elaeagnus. I-Rosmarinic acid i-polyphenolic eyakheke amanzi engamzimba wayo oyinhloko eyi-molecule ye-caffeic acid kanye ne-molecule ye-3,4-dihydroxy phenyl lactate (ie, Danshensu), egama lakhe lamakhemikhali [R €] α- {[3- ( 3,4-dihydroxy phenyl) -1-oxo-2-Isopropenyl] oxy} - 3,4-dihydroxy phenyl propionic acid, ifomula yayo yokwakheka kwamakhemikhali yile:

1. Yini izakhiwo zamakhemikhali ze-rosmarinic acid?
I-Rosmarinic acid ngokwayo iyi-antioxidant yemvelo emsulwa enomsebenzi oqinile we-antioxidant nomsebenzi we-antioxidant onamandla kuneVitamin E, i-caffeic acid, i-chlorogenic acid, i-folic acid, njll, esiza ukusiza ekubhujisweni kwamaseli wamahhala, ukuze i-rosmarinic acid inganciphisa ingozi yomdlavuza kanye ne-arteriosulinosis. Ngasikhathi sinye, i-rosmarinic acid inemisebenzi eqinile yokulwa nokuvuvukala, imisebenzi yokulwa ne-antibacterial, anti-tumor, futhi inezimpawu zokuvimbela ukutheleleka okungalapheki futhi okungamahlalakhona, imisebe ye-anti-ultraviolet futhi ivimbele ukonakaliswa kwe-elastin, okwenzile rosmarinic acid eyinhloko yezithasiselo zokugcoba. Njengamanje, i-rosmarinic acid inesikhundla esibalulekile ekwakhiweni kwemithi, izimonyo, ukudla, njll. Futhi isetshenziswa kabanzi empilweni yabantu yansuku zonke.




(1) Izakhiwo ezingokwenyama
I-Rosmarinic acid ngokwayo ingulutho oluncibilikiswa ngamanzi. Okuqukethwe kwe-rosemary kuphansi kakhulu, okuthi umbala we-rosemary ukhanya ophuzi ku-brown brown. Okuqukethwe okuphezulu kungumgubo omhlophe, okulula ukuwuthola umswakama futhi onambitheka okhethekile wekhambi we-rosemary. Iphuzu elincibilikayo lingu-171 ° C ~ 175 ° C, lapho ihlangana ne-chloride evundile - isixazululo se-potassium Ferricyanide, isibonisa ngokushesha oluhlaza okwesibhakabhaka.
I-Rosmarinic acid inokuqina okuhle, ngokusho kwemiphumela yokuhlolwa: kumthelela we-rosmarinic acid, usawoti ne-sucrose akunamphumela kukho; ngisho nemibandela emibili ye-pH kanye nokushisa idlula ukuqina kwe-ancinic acid kunomthelela omncane, kepha singathola isiphetho sokuthi ukugcinwa nokusetshenziswa ngaphansi kwezimo ze-pH <7 kanye lokushisa eliseduze lokushisa okujwayelekile yisimo esifanele kakhulu i-rosmarinic i-acid; Ngoba ukukhanya kulimaza kakhulu i-rosemary acid, kufanele sibe kude nokukhanya ngesikhathi sokuxhumana.
Ama-ion amabili wensimbi weCa2 + neMg2 + ayingozi ekuqineni kwe-rosmarinic acid. Amanye ama-iron ion anethonya elincane le-rosmarinic acid, ngakho-ke kufanele agcinwe kude ne-calcium ne-magnesium ions lapho exhumana; ukugcwala okuphansi kwe-sodium benzoate ne-potassium sorbate kuyingozi ekuqineni kwe-rosmarinic acid. Imithetho yokuxhumana kumele ibe nemithetho ecocekile yokusetshenziswa kwezengezo zokudla, kanye nezinhlinzeko zokungezelelwa okufanele nokususa; ukugxila okuphansi kwe-ascorbic acid nokunciphisa i-ejenti sodium metabisulfite i-rosmarinic acid kunomthelela omncane; kepha ithonya elikhulu ku-rosmarinic acid yi-oxidant hydrogen peroxide.



2. Kuphi umthombo we-rosmarinic acid?

1) I-Rosmarinic acid ezitshalweni
Le rosmarinic acid itholakala inani elikhulu lezitshalo, ikakhulukazi i-comfrey neLabiatae. Ososayensi abaningana bake bacwaninga ngale ndaba. Bektas Tepe et al. kweSalvia verticillate-ta (L.) subsp.Verticillata rosmarinic acid inenani lokuqongelelwa lafundelwa, eliphakeme kakhulu lingafinyelela (28.7 ± 0.89) μg / mg (isisindo esomile). Midori Natsume et al. kwenziwe izivivinyo ezingxenyeni ezihlukene zamaqabunga e-perilla ngezikhathi ezihlukile. Ukuhlola kubonise ukuthi amaqabunga we-perilla athela kakhulu ngo-Agasti, afinyelela (18.2 ± 0.2) mg / g (isisindo esisha).



2) I-Rosmarinic acid evela kusisombululo sesiko leseli
Umsebenzi we-rosmarinic acid uphezulu kakhulu, kepha isitshalo asiqukethe i-rosmarinic acid eningi futhi asinakukhiqizwa ngama-batches. Kodwa-ke, i-rosmarinic acid yi-metabolite yesibili yamaseli wezitshalo, ukuze amaseli wesitshalo aqhekeke futhi i-rosmarinic acid ikhiqizwe ngobukhulu ngokusebenzisa uketshezi lwesiko lezicubu. Ngo-1977, ososayensi baqala ukucwaninga ngale ndlela. Manje, ngentuthuko yesayensi nezobuchwepheshe, izindlela eziningi zitholakele zokuqinisa ukukhiqizwa kwe-rosmarinic acid ngamaseli wezitini zezitshalo. Inani leshukela kusisombululo se-Lavandula vera MM isiko lesiko lithinta ukuhlukaniswa kweseli nokukhiqizwa kwe-rosmarinic acid. Kubonakele ngokuhlolwa ukuthi umphumela omuhle utholakala kokuqukethwe ushukela ongu-7%, ukuze isisindo esomile seseli sibe ngama-29.2 g ilitha ngalinye. Ukukhiqizwa kwe-rosmarinic acid kufinyelela ku-507.5 mg / l. Ngaphezu kwezakhi eziqukethwe kwisifundo sokufunda, uPavlov et al. ngokuhlola kutholakale ukuthi ukukhiqizwa okuphezulu kakhulu kwe-rosmarinic acid kufinyelelwe (1870.6 mg ilitha) kungatholwa komoya ongcibilikisiwe oyi-30% no-300 rpm. Umehluko kaGeoriev et al. ekukhiqizweni kwe-rosmarinic acid eLavandula veraMM ekhethiwe amaseli ngezinto ezingaphili. I-Rosmarinic acid yayingcono ngaphansi kokufakwa kwe-methyl jasmonate kanye ne-disulfide inducer. I-50μmol / L methyl jasmonate yabangela ukunqwabelana kwe-rosmarinic acid kuze kufike ku-3348 mg ilitha elilodwa; Umphumela we-discride mncane kunalowo we-methyl jasmonate.
Ufuna ukwazi umsebenzi owengeziwe we-Rosemary pls uyaqhubeka nokusinaka.