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Ikarahun-pẹlẹbẹ Luteolin-Epa le jẹ alatako?

Ọjọ: 2019-10-28

Alailowaya-egboogi

Iṣẹ iṣẹ iṣako-iredodo ti Luteolin ni a fihan ni agbara rẹ lati dinku iṣẹ-ṣiṣe ti awọn olutọsọna ẹda transpaili ifosiwewe ati dinku iṣelọpọ ti cytokines pro-inflammatory ati awọn olulaja iredodo. Chen et al rii pe pretreatment pẹlu Luteolin dinku pro-iredodo factor tumor negirosisi factor-α (TNF-α) ti iṣelọpọ nipasẹ idinku lipopolysaccharide (LPS) -Tawon iṣọn alveolar macrophage MH-S ẹyin 、 interleukin-6 (IL-6) ati awọn olulaja ti iredodo nitric oxide (KO) 、 prostaglandin E2 (PGE2), awọn abajade RT-PCR fihan pe Luteolin wa ni ipele mRNA ikosile ti inducible KO synthase (iNOS) ati cyclooxygenase-2 (COX-2) ti ni idiwọ. Awọn ijinlẹ siwaju ti fihan pe ẹrọ ti lasan ti o wa loke ni pe Luteolin dinku iṣẹ-ṣiṣe ti iparun ifosiwewe-kappa B (NF-κB), ṣe idiwọ iṣẹ ṣiṣe-DNA, ati awọn bulọọki gbigbe ọkọ iparun ti NF-κB P65. Ni akoko kanna, Luteolin tun dinku iṣẹ ti mimu amuaradagba ṣiṣẹ-1 (AP-1) ati dinku iṣẹ ṣiṣe adehun DNA rẹ. Luteolin ṣe ipa ipa-iredodo nipasẹ idilọwọ awọn ipa ọna NF-κB ati AP-1. Luteolin tun le ṣe idiwọ amuaradagba inhibitory NF-κB palmitate-inhibitory (inhibitor ti NF-κB, IκB) α NF-κB inhibitory factor kinase β (NF-κB inhibitory cofactor kinase β, IKKβ) in the umbilical vein endothelial ẹyin phospholation -κB mu ṣiṣẹ ati dinku igbona, nitorinaa dinku idinku isọ iṣan.
Awọn olugba Toll-like (TLRs) jẹ ọkan ninu awọn olugba iranti olurannileti cellular ati awọn olugba idanimọ awoṣe pathogen ninu eto ajẹsara, eyiti o le kọja interferon-β TIR domain-ti o ni ifikọra ti n ṣafihan interferon-β, ọna ọna ami ifihan igbẹkẹle igbẹkẹle TRIF nfa idahun iredodo ati pe o ṣe ipa pataki ninu awọn Idahun iredodo nla. Lee et al kọkọ ṣe itọju awọn sẹẹli pẹlu Luteolin, lẹhinna mu awọn sẹẹli pọ pẹlu TLR3 agonist poly (I: C) ati TLR4 agonist LPS lẹsẹsẹ, ati pe o rii pe Luteolin dinku idinku awọn jiini TLR jiini TNF-α, IL-6, IL - 12, IL-27, IP-10 ifosiwewe chemotactic (amuaradagba interferon-inducible-10), interferon-β, IFNβ) ati chemokine (motif CXC) ligand 9, CXCL9) ikosile chemokine. Pẹlupẹlu, Luteolin ṣe idiwọ iṣẹ-ṣiṣe ti ifosiwewe ilana ilana interferon 3 (IRF3) ati NF-κB ninu awọn sẹẹli pẹlu ikosile itẹramọlẹ ti TLR4 ati TRIF. Gbogbo awọn wọnyi tan imọlẹ ipa inhibitory ti Luteolin lori TLR3 ati iṣẹ TLR4. TANK-binding kinase 1 (TBK1) ṣe awọn ohun elo phoFhorylates IRF3 ati mu IRF3 ṣiṣẹ. Iwadi ti fihan pe Luteolin le ṣe idiwọ iṣẹ-ṣiṣe kinase TBK1 ni ọna-igbẹkẹle iwọn lilo. Luteolin dinku iredodo nipa didena Titẹẹẹti olutayo TRIF-like.



Carrageenan jẹ polysaccharide imi-ọjọ ti o fa idamu iredodo nipasẹ muu NF-κB ṣiṣẹ. Ni awọn adanwo vivo fihan pe pretreatment ti 50 miligiramu / kg Luteolin ṣe pataki idiwọ carrageenan-induced paw edema. Luteolin tun ṣe idiwọ granuloma Asin ati wiwu ọkọ ofurufu, o si ṣe idiwọ afikun ti awọn sẹẹli alaiṣan Asin ti a fa nipasẹ concanavalin A ni ọna igbẹkẹle-igbẹkẹle. Iwadi siwaju sii fihan pe iwọnyi le jẹ ibatan si idiwọ ti iṣẹ-ṣiṣe COX-2 nipasẹ Luteolin.

Abajade iwadii ti fihan pe Luteolin ni iṣẹ ṣiṣe egboogi-iredodo mejeeji ni fitiro ati ni vivo.